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In 2023 Lilly published results of its phase 2 trial for orforglipron, a once-daily oral drug which achieved up to 14.7% mean weight reduction at 36 weeks, and Pfizer has completed phase 2 trial for its oral drug danuglipron and is now optimising the formulation

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Severe upper abdominal pain with or without vomiting could indicate pancreatitis, while right upper abdominal pain with fever or yellowing of the skin/eyes might suggest gallbladder problemsboth require urgent medical assessment (call NHS 111 or go to A&E if symptoms are severe)

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